I'd guess that a large percentage of OMV users are doing this. The more advanced/experienced users probably do a lot more, as well, but OMV will certainly do what you're looking for. I'm personally about to switch from a Windows Server based solution to OMV. I played around in a virtual machine for a couple of weeks, though. There are sometimes little glitches or unexpected behavior that you may want to iron out before a live installation.
I'm preparing my media to do a new install of OMV either later tonight or tomorrow. Maybe I'll document my process. I'm no expert, so maybe it will be useful to beginners as I run into mistakes and try to work around them.
great, yeah a never done this before guide would be super useful.