I found something out.
If the container is running and the VPN connection is up i lose the connection.
If i run a cmd in the docker container "ip r" i see all routes
0.0.0.0/1 via 100.97.0.1 dev tun0
default via 172.17.0.1 dev eth0
184.108.40.206 via 172.17.0.1 dev eth0
100.97.0.0/16 dev tun0 proto kernel scope link src 100.97.0.32
220.127.116.11/1 via 100.97.0.1 dev tun0
172.17.0.0/16 dev eth0 proto kernel scope link src 172.17.0.3
192.168.1.0/24 via 172.17.0.1 dev eth0
if i remove 18.104.22.168/1 via 100.97.0.1 dev tun0 by run ip route del 22.214.171.124/1 via 100.97.0.1 dev tun0 the web interface from Transmission comes back!
If i check the traffic in the container it is still using the VPN connection.
curl ifconfig.co returns the WAN IP of the VPN connection.
If i run the same command on the Raspberry Pi I get my own WAN IP, everything looks good sofar.
But how can i fix the issue without having remove the route manually?