After transferring more files I'm running into the issue again today. I started transferring a bunch of photos, noticed the slowdown, checked my syslog and these entries started popping up:
Sep 23 13:29:49 omv collectd[883]: rrdcached plugin: rrdc_update (/var/lib/rrdcached/db/localhost/cpu-0/cpu-wait.rrd, [1474651777:1165990], 1) failed with status -1.
Sep 23 13:29:49 omv collectd[883]: Filter subsystem: Built-in target `write': Dispatching value to all write plugins failed with status -1.
Sep 23 13:29:49 omv collectd[883]: rrdcached plugin: rrdc_update (/var/lib/rrdcached/db/localhost/cpu-0/cpu-system.rrd, [1474651777:82328], 1) failed with status -1.
Sep 23 13:29:49 omv collectd[883]: Filter subsystem: Built-in target `write': Dispatching value to all write plugins failed with status -1.
Sep 23 13:26:31 omv collectd[883]: rrdcached plugin: rrdc_update (/var/lib/rrdcached/db/localhost/rrdcached/operations-receive-flush.rrd, [1474651591:18990], 1) failed with status -1.
Sep 23 13:26:31 omv collectd[883]: Filter subsystem: Built-in target `write': Dispatching value to all write plugins failed with status -1.
Sep 23 13:26:31 omv collectd[883]: rrdcached plugin: rrdc_update (/var/lib/rrdcached/db/localhost/rrdcached/operations-receive-update.rrd, [1474651591:588684], 1) failed with status -1.
Sep 23 13:26:31 omv collectd[883]: Filter subsystem: Built-in target `write': Dispatching value to all write plugins failed with status -1.
Sep 23 13:24:54 omv collectd[883]: rrdcached plugin: rrdc_update (/var/lib/rrdcached/db/localhost/df-media-57c40fe1-f0fc-4e43-934f-7c2cfa55bd99/df_complex-free.rrd, [1474651477:5077551886336.000000], 1) failed with status -1.
Sep 23 13:24:54 omv collectd[883]: Filter subsystem: Built-in target `write': Dispatching value to all write plugins failed with status -1.
Sep 23 13:24:54 omv collectd[883]: rrdcached plugin: rrdc_update (/var/lib/rrdcached/db/localhost/df-root/df_complex-used.rrd, [1474651477:1720082432.000000], 1) failed with status -1.
Sep 23 13:24:54 omv collectd[883]: Filter subsystem: Built-in target `write': Dispatching value to all write plugins failed with status -1.
Is my setup really that unique that no one's run into this issue or at least these error messages before?