Could be, I upgraded from 3 to 4, but for 5 I decided on a clean install and having tested the ISO and the Debian net install + script in a VM, I finally decided to go with the ISO.
Would you mind sending me the output of systemctl list-units --full --no-pager? I'd like to compare our running services (in private is fine). Oh and: is your /etc/resolv.conf a symlink by any chance?