I recently bought an ORICO 5 bay enclosure and came across this post because I noticed that the disks were spinning down, even when I have this setting deactivated for all of them.
All my disks are used in a mergerfs pool.
For now, I have noticed that, indeed, some disks spin down after some inactivity, so it seems that he unit has some kind of hardware energy management system.
In my case it doesn't affect the normal use, since whenever I need a file that is on a disk, it takes a few seconds but then I can access normally. No problems detected on units unmounting, etc. but will report in a few days.